After leaving the Harland and Wolff Shipyard for sea trials, the next stop was Southampton, her homeport. The RMS Titanic arrived in Southampton on APril 3rd, which much to do before passengers boarded for the inaugural voyage. Most of the crew that would staff the Titanic were from Southampton, as was typical for ships then.
On April 10th the Titanic left Southampton for Cherbourg France, then Queenstown Ireland (now Cobh) and then set sail for New York. The Titanic took a more southerly route, ironically to avoid the reported iceberg field, and about 450 miles off the coast of Newfoundland, hit an iceberg and sank.
The last known position of the the Titanic was 41° 46' N 50° 14' W 49W. Because the Titanic broke apart, the wreck location for the bow and stern and the debris field each have their own coordinates.